TREG cell therapy
نویسندگان
چکیده
منابع مشابه
Can Treg elimination enhance NK cell therapy for AML?
In this issue of Blood, Bachanova et al describe how modulation of the inhibitory tumor environment may enhance natural killer (NK) cell clinical activity and produce encouraging results in the treatment of refractory acute myeloid leukemia (AML). NK cells are highly proliferative, early responders of the innate immune response that in preclinical models can exert potent activity against a wide...
متن کاملCan Treg therapy prevent GVHD?
In this issue of Blood, Brunstein and colleagues report the results of the first study to test the safety of human umbilical cord blood– derived regulatory T cells (Tregs), an approach designed to decrease graft-versus-host disease.1 Transplanters, like Sisyphus of myth, have struggled mightily with trials of pharmacologic immunosuppressive drugs—we roll the rock up the mountain, only to see it...
متن کاملTranslating Treg Therapy in Humanized Mice
Regulatory T cells (Treg) control immune cell function as well as non-immunological processes. Their far-reaching regulatory activities suggest their functional manipulation as a means to sustainably and causally intervene with the course of diseases. Preclinical tools and strategies are however needed to further test and develop interventional strategies outside the human body. "Humanized" mou...
متن کاملCombination B7-Fc fusion protein treatment and Treg cell depletion therapy.
PURPOSE A B7.1 fusion protein consisting of the extracellular domains of human B7.1 and the Fc portion of human IgG1, called B7.1-Fc, was generated and evaluated for its antitumor potential when used alone or in combination with regulatory T (Treg) cell depletion. METHODS A human B7.1-Fc fusion protein was constructed, expressed, purified, and examined for its antitumor activity in experiment...
متن کاملLkb1 maintains Treg cell lineage identity
Regulatory T (Treg) cells are a distinct T-cell lineage characterized by sustained Foxp3 expression and potent suppressor function, but the upstream dominant factors that preserve Treg lineage-specific features are mostly unknown. Here, we show that Lkb1 maintains Treg cell lineage identity by stabilizing Foxp3 expression and enforcing suppressor function. Upon T-cell receptor (TCR) stimulation...
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ژورنال
عنوان ژورنال: Nature Reviews Rheumatology
سال: 2010
ISSN: 1759-4790,1759-4804
DOI: 10.1038/nrrheum.2009.244